About the Laboratory
The current genomic challenge is to understand how proper gene expression is orchestrated. Recent studies indicate that genomes are organized into dynamic three-dimensional physical networks, which are required for correct gene expression. The functional (physical) connectivity between genes and regulatory DNA elements must be mapped to understand how correct gene expression is obtained and ultimately how the genome functions. In order to quantitatively measure the intensity of individual DNA contacts within the genome, we make use of Chromosome Conformation Capture (3C) and 3C Carbon Copy (5C) technologies.